ZelNate DNA Immunostimulant for Cattle aids in the treatment
of bovine respiratory disease (BRD) due to Mannheimia haemolytica in cattle 4
months of age and older. ZelNate should be administered at the time of, or
within 24 hours after, a perceived stressful event. ZelNate is a
bacterial-produced plasmid DNA with a liposome carrier that stimulates the
innate immune system in cattle. The innate immune system has been shown to
provide a potent, rapid, nonspecific, protective response to infectious agents,
such as those that can lead to Bovine Respiratory Disease (BRD). BRD is a
serious condition that commonly causes lung lesions, reduced lung capacity, and
mortality. As a stand-alone therapy, ZelNate has been shown to significantly
reduce lung lesions associated with BRD when administered in the face of
disease challenge, and to significantly reduce the risk of mortality when
administered in the face of clinical BRD. ZelNate requires mixing. The
freeze-dried product is packaged with two different sterile diluents. Mixing
process must be completed in the proper order prior to use. Inject 2 ml IM at
the time of, or within 24 hours after, a perceived stressful event (ie.
weaning, shipping, commingling, or adverse environmental conditions). Do not
administer within 21 days of slaughter.
While vaccines work with the adaptive immune
response to target specific pathogens, sometimes requiring days or weeks to
develop, immunostimulants trigger a rapid and broad response to infection via
the innate immune system. The key difference between ZelNate and other
immunostimulants lies in its revolutionary DNA-liposome complex. The ZelNate
DNA has a unique code that mimics infection, causing the animal's immune system
to recognize ZelNate as foreign. This jumpstarts the innate immune system in
cattle.